Through the courtesy of Professor Andrew Adjei, MHIRT trainees and mentors work alongside immunologists and pathologists in well equipped laboratories at Korle Bu Teaching Hospital. For 2015, the MHIRT team consisting of students from Morehouse College, Morehouse School of Medicine and Howard University, and faculty trainers from the Pathology Department and Noguchi Memorial Medical Research Institute, made significant research advances in the study of malaria in pregnant women living in malaria endemic regions in Ghana. The Team focused on the increased serum levels of free Heme that causes tissue damage, occlusion of brain microvessels, activation of microvascular endothelial and glial cells, focal inflammation, activation of apoptotic pathways and neuronal tissue damage that impacts pregnancy outcomes. In this current study they measured the levels of malaria‐induced heme and HO‐1, and determined their effects on pregnancy outcomes. Their hypothesis is that pregnant women with malaria infection will have high levels of Heme/HO‐1 and more adverse pregnancy outcomes than pregnant women without malaria. Initial results indicate that Plasmodium induced Heme plays an important role in the development of the fetus during pregnancy and that efforts to reduce Heme as part of the overarching malaria control program will go a long way to save lives of pregnant mothers and their infants.
Heme-Mediated Induction of CXCL10 and Depletion of CD34+Progenitor Cells Is Toll-Like Receptor 4 Dominant. 2015 Carmen M. Dickinson-Copeland, Nana O. Wilson, Mingli Liu, Adel Driss, Hassana Salifu, Andrew A. Adjei, Michael Wilson, Ben Gyan, Daniel Oduro, Kingsley Badu, Felix Botchway, Winston A. Anderson, Vincent Bond, Methode Bacanamwo, Shailesh Singh, and Jonathan K. Stiles. PLOS One 10(11)
The University of Ghana Health Science Center and Korle Bu Hospital
Through the sponsorship of Professor Albert Amoah, National Diabetes Management and Research Centre, Arthur Sackeyfio, School of Pharmacy, Allen Steele-Dadzie, Polyclinic Asthma Clinic, Dr. Georgia Dunston, Howard University National Human Genome Center, and Dr. Earl Ettienne, School of Pharmacy, pursued a project titled, Pharmacogenetic Studies of Depression in Co-morbid Diabetes and Asthma.
The long range goal of this research project is to study the impact of population-based genetic variation on patient response to pharmaceutical treatment of depression in diabetes and asthma. The MHIRT 2015 team returned to Accra, to expand upon the preliminary data collected from summer 2014 on patients using the National Diabetes Center and the Polyclinic Asthma Clinic at the Korle Bu Teaching Hospital. At the National Diabetes Center in Accra, they assessed the incidence of mood disorders through the administration of two questionnaires. A total of 199 patients were interviewed. Patient medical records were also accessed to collect data on past medical history, medication profile, and demographics. The MHIRT Team met all their research objectives and made significant accomplishments on pharmacogenetic studies of depression in co‐morbid diabetes and asthma. In this retrospective study that involved more than 400 patients, the students gained immense experience on the clinical treatment of patients with asthma and diabetes, and the impact of population based genetic variation on patient response to pharmaceutical treatment of depression in diabetes and asthma. This investigation is on-going at the university.
University of Ghana-Legun
Korle Bu Teaching Hospital